All you want to know about stem cell banking

May 15, 2010

Courtesy by: Mumbaimirror.com
Among the many decisions would-be-parents have to take, whether or not they should preserve their child’s cord blood cells is one such major decision they have to take. Here is some info which will let you decide whether this breakthrough in regenerative medicine works for you.

What is stem cell therapy?
Stem cells are nothing but master cells that regenerate and turn into cells that form tissues, organs and systems. These cells are undifferentiated or blank cells that do not have a specific function. Each stem cell has the potential to become another cell with a more specialised function. Also serving as a kind of repair system for the body, stem cells can divide repeatedly and then differentiate and replenish cells damaged by the various life-threatening diseases.

How effective is it?
The cord blood stem cells can be used to cure about 70 odd illnesses. Banking stem cells present in your child’s umbilical cord is particularly beneficial to treat blood-related genetic diseases. Now the benefits of this therapy are being assessed on lifestyle disorders like arthritis, heart ailments and diabetes. In fact, banking cord blood cells can also help treat siblings and other family members provided they are compatible with the individual seeking treatment.

Sagar Gopal, a resident of Chembur opted for cord stem cell banking for his little one on February 7 this year. “I heard about cord stem cell banking from a friend of mine. After doing the necessary research I realised that cord stem cell banking will be beneficial because a lot of research is on its uses. I think by taking this small step I have secured my child’s life against several life threatening diseases,” says Gopal.

Sources
Stem cells can be derived from various sources such as the bone marrow, embryos obtained by in vitro fertilization, amniotic fluid, umbilical cord blood and menstrual blood.

Bone Marrow – The bone marrow is an extremely rich and the earliest known source of somatic stem cells. Drawn from the spongy tissue found in the centre of bones, the main function of these stem cells is to make blood cells that circulate in our bodies and fight infection.

Umbilical Cord – The other rich source of stem cells is the blood left over in the umbilical cord and placenta of a newborn child. Till recently, this blood was often discarded as medical waste. However, now that umbilical cord blood is known to be a rich source of stem cells, more people are choosing to bank these cells for its potential future use.

Menstrual blood – Menstrual blood too is a rich source of stem blood cells. The advantage of this is that tissue collection can be done easily at home with the help of a menstrual cup. Also the person does not need anaesthesia and the process involved is inexpensive too. However, there is a risk of contamination so the collected sample has to be sterilised within 48 hours and stored at a temperature of -200 degrees.

Advantages of deriving stem cells from umbilical cord as compared to other sources
Removing stem cells from the umbilical cord is simpler. Usually the umbilical cord that connects the foetus with the mother is cut at the time of delivery and discarded. However, in this technique, the blood remaining in the umbilical cord that is full of stem cells is separated and stored in stem cell banks. These stem cells are similar to those found in the bone marrow and have already been used to treat leukaemia (blood cancer).

Mayur Abhaya, executive director of Life Cell, a stem cell bank in India, states, “The advantage of banking stem cells through the umbilical cord is that cord blood’s chances of matching are 20 times higher. Using cord blood cells mean that it has a lower rejection rate by the body.”

How is it stored?
As of now there are three private stem cell banks in India. These include the one run by Reliance in Mumbai, CryoCell stem bank run in New Delhi and Life Cell run in collaboration with Cryo-Cell International, USA in Chennai.

You can now preserve your newborn’s cord blood at any bank for a payment of Rs70,000 for 20 years.

However, the American Academy of Pediatrics (AAP) does not recommend private cord blood storage unless a family member has a medical condition that might be helped by stem cell transplant. The conditions include leukaemia, lymphoma, neuroblastoma, sickle cell anaemia, thalassemia. Instead, AAP urges parents to donate the cord blood cells to a bank for general use by public.

BOX
Across the world, stem cell transplants have been used since the 1960s to treat a variety of diseases such as: Acute Leukaemia, Histiocytic Disorders, Inherited Immune System Disorders, Combined Immunodeficiency Inherited Metabolic Disorders, Inherited Platelet Abnormalities, Refractory Anaemia (RA), Plasma Cell Disorders, Research on for Alzheimer’s Disease, Cardiac Disease, Diabetes, Multiple Sclerosis, Muscular Dystrophy, Parkinson’s Disease, Spinal Cord, Stroke


Notes: 6th National Thalassemia Conference & Workshops

December 25, 2009

6th National Thalassemia Conference & Workshops
17th – 19th December 2009
Lahore

Day 1: Conference Inauguration – Pearl Continental Hotel, Lahore

Ceremony started with Tilawat-e-Quran at 4 pm, Mr. Hussain Jafri, Secretary General TFP Punjab Chapter gave Welcome Address, and Dr. Yasmeen Rashid Secretary General TFP gave introduction of TFP.
TFP was established in 2004, Thalassemia patients registered with TFP are 25000, 39 NGOs working with TFP till date.

Prevention program being designed and developed by the help of WHO.

More than 15 billion are being subjected for the prevention by Punjab Government.

Mr. Iqbal, TFP Exec. Comm. Member being called to let us know the feedback of a Thalassemic parent, Dr. Jovaria Manna, Chairperson, Medical Advisory Board briefed us about scientific sessions and workshops of the next two days.

Dr. Jovaria informed us about Uniform Protocol, book on iron chelation therapy guideline which she has edited and being distributed all over Pakistan.

Mr. Iqbal told us about his blood bank and Thalassemia center, which is in Karachi and working successfully.

Address by Guest of honor Prof. Majeed Chaudhry, Principal, FJMC & Prof. Humayun Maqsood, Principal, FMCMD.

Both of them appreciated TFP’s work and event and and promised to support conference by all means.

Lt. Gen (R) Moin-ud-din Haider, President TFP thanked all for attending, requested for moral and monetary support for TFP and societies, told us about government being concerned in Thalassemia issue these days and gave shields to the mentioned below patients on their achievements.

1) Ayesha Murtuza from Abbotabad – LLB
2) Laiba Mukhtar from Lahore – 3rd position in Inter & 1st in I.COM
3) Master Abdul Samad – 5th passed Hafiz-e-Quran
4) Mujtaba Shareef – Hafiz-e-Quran
5) Miss. Atiya Kamran from Karachi – Inter pass, married
6) Mr. Ejaz Haider from Karachi – Volunteer for Fatimid
7) Ameen Tipu – Earning, married & have two kids
8) Usman – Hafiz-e-Quran

– End of day 1 –

Day 2: Patient Safety Awareness Workshop in Collaboration with World Health Organization – Fatima Memorial College of Medicine & Dentistry, Lahore

Started at 9:30 am with Tilawat-e-Quran, Dr. Yasmeen Rashid gave briefing over the workshop objectives; workshop was conducted by WHO on their World Alliance Of Patient Safety.

She briefed about iron chelation, transfusion, screening, hepatitis, aids, etc.

She even requested the NGOs to care about screening, cleaning and hygiene.

Later on Mr. Hussain Jafri briefed us about World Alliance of Patient Safety program.

WHO launched this program in October 2004.

Programs started under World Alliance:
1) Patients for patient safety
2) Patient safety research
3) WHO patient safety campaigns
4) Education and training
5) Implementing change

You can read about IAPO – International Alliance of Patients Organization at their website: IAPO

After Mr. Hussain, Dr. Jovaria came on dice to give us guidance over Patients Safety, she told us a patient should be aware of everything, he should ask the nurse while getting transfuse about screening, blood bag details, make sure that blood belongs to him, patient should get vaccination done, she even advice to get splenotomy done by good doctor not by any general surgeon.

After Dr. Jovaria, Question and Answer session was conducted, followed by panel-list of three doctors, three society member and three patients.

I was given the chance to be among the three patients, was given chance to brief over my activities and Thalassemia.com.pk, which got appreciated by all the people attending.

– End of day 2 –

Day 3: Prevention & Treatment of Hepatitis B & C of Patients Receiving Multiple Blood Transfusions – Fatima Jinnah Medical College, Lahore

Day 3rd was a bit hard to manage, as there were two things going on side by side at the same timings, one side conference over Hepatitis, other side scientific sessions over exjade, prevention & genetic counseling.

Not much new was being told, but there was a session which I wanted to attend badly and I have made notes of it, sharing it with you

Management of Pregnancy in Thalassemia Major – Dr. Yasmeen Rashid:

Patient who want to start new family should work hard to get her ferritin as low as 500, and must maintain her hemoglobin at 10 – 11 gram.

Pre Pregnancy Counseling:
Iron chelation is discontinued for 9 months

Pre Pregnancy Evaluation:
Cardiac, Liver, Vessels, Pancreas, Viral Infection, Iron Status – all things should be monitored closely.

During Pregnancy:
1) Iron should be around 300 to 500 for better health of baby.
2) Hemoglobin should be maintained at 10 – 11 gram.
3) Low blood transfusion, small quantity every 10 to 15 days to give enough oxygen to the body.
4) Vital signs should be monitored during transfusion.
5) Discontinue iron chelation.
6) Continuous check on ferritin level.
7) Cardiac monitoring every 3 months.
8) Endocrine function, oral glucose test should be done
9) Last but not the least, Best doctors!

Effects on the fetus if anything is wrong:
1) Fetal Hypoxia
2) IUGR
3) Premature Labor
4) Fetal Demise

Delivery:
One should wait for normal delivery to happen, but as it takes lots of efforts/energy so the patient should be monitored closely for cardiac functions.

In case of IUGR or Fetal distress cesarean should be performed.

Iron Chelation should be started within the first week after delivery.

– End of day 3 –

Program Guide: Day 1 , Day 2 , Day 3 a , Day 3 b

Pictures: 6th National Thalassemia Conference & Workshops

Note: I have made notes of my interested topics only, but I have attended almost every session… If you want to know about anything kindly drop a comment I will try to respond as soon as possible… But to be frank there wasn’t much new knowledge to hear.


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